Levels of Superoxide Dismutases, Glutathione, and Poly(ADP-ribose) Polymerase in Radioresistant Human KB Carcinoma Cell Line
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چکیده
منابع مشابه
Induction of radioresistant nasopharyngeal carcinoma cell line CNE-2R by repeated high-dose X-ray irradiation
Background: All To enhance the curative effect of radiotherapy, we established a radio-resistant cell line, CNE-2R from CNE-2, a radio-sensitive type of CNE, through repeated irradiation. The developed cell line provides a basis for further studies on the radio-resistance of CNE and the molecular mechanism of radiotherapy sensitization drugs. Materials and Methods: The CNE-2 cell line was selec...
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Yuewei Sheng,† Isabel A. Abreu,*,‡,§ Diane E. Cabelli,* Michael J. Maroney,* Anne-Frances Miller,* Miguel Teixeira,*,‡ and Joan Selverstone Valentine*,†,∇ †Department of Chemistry and Biochemistry, University of California Los Angeles, Los Angeles, California 90095, United States ‡Instituto de Tecnologia Química e Bioloǵica Antońio Xavier, Universidade Nova de Lisboa, Av. da Repub́lica, 2780-157...
متن کاملSuperoxide radical and superoxide dismutases.
O2- oxidizes the [4Fe-4S] clusters of dehydratases, such as aconitase, causing-inactivation and release of Fe(II), which may then reduce H2O2 to OH- +OH.. SODs inhibit such HO. production by scavengingO2-, but Cu, ZnSODs, by virtue of a nonspecific peroxidase activity, may peroxidize spin trapping agents and thus give the appearance of catalyzing OH. production from H2O2. There is a glycosylate...
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Introduction: The objective of this work was to investigate the therapeutic effect of a combination of hyperthermia at 43oC exposured for 20, 40, 60 min with 6MeV electron beams at different radiation doses (2, 4, 6 Gy) compared to radiation alone. Materials and Methods: In this in vitro study, HeLa cells were exposed to either: 6MeV electron beams at diffe...
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Objective: Cancer is a major health problem worldwide and current therapies for cancer are often limited by short-term efficacy due to drug resistance. There has been much interest in the use of naturally occurring compounds with chemo-preventive and chemotherapeutic properties in the treatment of cancers. Rose is one of the most important groups of ornamental plants which their fruits and flo...
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ژورنال
عنوان ژورنال: Japanese Journal of Cancer Research
سال: 1997
ISSN: 0910-5050
DOI: 10.1111/j.1349-7006.1997.tb00331.x